Structure

    redEnd--??1D-GalNAc,p(--3b1D-Gal,p)--6b1D-GlcNAc,p(--4b1D-Gal,p)--3a1L-Fuc,p$MONO,Und,-H,0,redEnd

The O-glycome of human nigrostriatal tissue and its alteration in Parkinsons disease

GlyTouCan Accession Number: Loading...

Peak Intensity
290.35 1.9
299.26 2.1
306.16 11.3
307.03 1.0
312.07 1.3
323.99 1.3
341.2 1.7
366.29 3.2

Annotations:

CY ?1D-GalNAc,p/#ccleavage--6b1D-GlcNAc,p(--4b1D-Gal,p/#ycleavage)--3a1L-Fuc,p$MONO,Und,-H,0,redEnd Z redEnd--??1D-GalNAc,p(--3b1D-Gal,p)--6b1D-GlcNAc,p/#zcleavage$MONO,Und,-H,0,redEnd
371.23 3.5
384.26 22.3

Annotations:

Y redEnd--??1D-GalNAc,p(--3b1D-Gal,p)--6b1D-GlcNAc,p/#ycleavage$MONO,Und,-H,0,redEnd
389.27 3.1
403.23 1.5
407.11 2.0
419.38 1.9
424.89 1.0
425.36 3.1
443.18 1.2
444.18 1.2
449.21 1.7
461.2 2.7
476.25 1.1
479.18 2.8
479.44 1.7
489.11 1.1
509.27 11.1
510.35 5.0

Annotations:

B ?1D-GalNAc,p/#bcleavage--6b1D-GlcNAc,p(--4b1D-Gal,p)--3a1L-Fuc,p$MONO,Und,-H,0,redEnd
521.2 5.4
521.6 1.4
522.11 1.1
535.48 1.6

Annotations:

ZZ redEnd--??1D-GalNAc,p(--3b1D-Gal,p/#zcleavage)--6b1D-GlcNAc,p(--4b1D-Gal,p/#zcleavage)--3a1L-Fuc,p$MONO,Und,-H,0,redEnd
538.6 1.1
551.34 23.1

Annotations:

ZZ redEnd--??1D-GalNAc,p(--3b1D-Gal,p)--6b1D-GlcNAc,p(--4b1D-Gal,p/#zcleavage)--3a1L-Fuc,p/#zcleavage$MONO,Und,-H,0,redEnd ZZ redEnd--??1D-GalNAc,p(--3b1D-Gal,p/#zcleavage)--6b1D-GlcNAc,p(--4b1D-Gal,p)--3a1L-Fuc,p/#zcleavage$MONO,Und,-H,0,redEnd
551.82 2.7
553.39 1.2

Annotations:

YZ redEnd--??1D-GalNAc,p(--3b1D-Gal,p/#ycleavage)--6b1D-GlcNAc,p(--4b1D-Gal,p/#zcleavage)--3a1L-Fuc,p$MONO,Und,-H,0,redEnd ZY redEnd--??1D-GalNAc,p(--3b1D-Gal,p/#zcleavage)--6b1D-GlcNAc,p(--4b1D-Gal,p/#ycleavage)--3a1L-Fuc,p$MONO,Und,-H,0,redEnd
557.7 2.4
587.23 3.5

Annotations:

YY redEnd--??1D-GalNAc,p(--3b1D-Gal,p)--6b1D-GlcNAc,p(--4b1D-Gal,p/#ycleavage)--3a1L-Fuc,p/#ycleavage$MONO,Und,-H,0,redEnd YY redEnd--??1D-GalNAc,p(--3b1D-Gal,p/#ycleavage)--6b1D-GlcNAc,p(--4b1D-Gal,p)--3a1L-Fuc,p/#ycleavage$MONO,Und,-H,0,redEnd
588.17 2.9
600.29 1.5

Annotations:

^{0,3}A_{GalNAc} ?1D-GalNAc,p/#acleavage_0_3--6b1D-GlcNAc,p(--4b1D-Gal,p)--3a1L-Fuc,p$MONO,Und,-H,0,redEnd
620.33 1.5
636.19 1.1
641.03 1.1
654.98 1.5
662.98 1.9
678.61 1.7
682.92 1.9

Annotations:

^{1,5}A_{GalNAc}Z ?1D-GalNAc,p/#acleavage_1_5(--3b1D-Gal,p)--6b1D-GlcNAc,p(--4b1D-Gal,p)--3a1L-Fuc,p/#zcleavage$MONO,Und,-H,0,redEnd
689.19 1.2
691.11 1.1
691.48 2.5
692.33 6.2
710.76 2.4
715.34 19.6

Annotations:

Z redEnd--??1D-GalNAc,p(--3b1D-Gal,p)--6b1D-GlcNAc,p(--4b1D-Gal,p/#zcleavage)--3a1L-Fuc,p$MONO,Und,-H,0,redEnd Z redEnd--??1D-GalNAc,p(--3b1D-Gal,p/#zcleavage)--6b1D-GlcNAc,p(--4b1D-Gal,p)--3a1L-Fuc,p$MONO,Und,-H,0,redEnd
715.81 4.3
716.4 2.4
731.17 1.1

Annotations:

Z redEnd--??1D-GalNAc,p(--3b1D-Gal,p)--6b1D-GlcNAc,p(--4b1D-Gal,p)--3a1L-Fuc,p/#zcleavage$MONO,Und,-H,0,redEnd
733.36 47.1

Annotations:

Y redEnd--??1D-GalNAc,p(--3b1D-Gal,p)--6b1D-GlcNAc,p(--4b1D-Gal,p/#ycleavage)--3a1L-Fuc,p$MONO,Und,-H,0,redEnd Y redEnd--??1D-GalNAc,p(--3b1D-Gal,p/#ycleavage)--6b1D-GlcNAc,p(--4b1D-Gal,p)--3a1L-Fuc,p$MONO,Und,-H,0,redEnd
734.4 6.3
734.65 1.1
736.59 2.1
741.45 2.4
741.97 1.6
742.37 5.6
742.92 1.7
749.93 2.5
755.58 1.6
756.22 1.8
771.42 1.5
775.9 3.1

Annotations:

^{2,5}A_{GalNAc} ?1D-GalNAc,p/#acleavage_2_5(--3b1D-Gal,p)--6b1D-GlcNAc,p(--4b1D-Gal,p)--3a1L-Fuc,p$MONO,Und,-H,0,redEnd
777.8 5.2
784.3 3.5
785.67 2.2
792.39 1.4

Annotations:

^{0,2}A_{GalNAc} ?1D-GalNAc,p/#acleavage_0_2(--3b1D-Gal,p)--6b1D-GlcNAc,p(--4b1D-Gal,p)--3a1L-Fuc,p$MONO,Und,-H,0,redEnd
793.02 4.1
797.74 3.1
807.4 2.1
809.21 1.3
813.75 2.0
815.08 4.0
815.38 1.1
815.63 4.6
816.32 1.2
819.31 1.6
821.78 1.9
822.98 1.1
823.32 4.7
823.78 1.5
824.03 1.8
834.63 1.5
835.38 15.7
835.85 6.1
836.2 3.8
836.53 7.0
838.54 1.4
853.4 1.9
854.5 1.6
855.77 1.2
858.09 1.2
859.17 1.3
860.66 1.7
864.1 3.0
865.64 7.3

There are 19 similar spectra:

Id Structure Score

1.00

6737

0.89

5573

0.87

0.86

0.86

7172

0.86

5787

0.83

5574

0.82

4265

0.80

5250

0.80

3881

0.77

0.77

0.74

7652

0.74

7668

0.74

3125

0.73

3975

0.70

7223

0.66

5791

0.50

Structure Format

SNFG Oxford Text

Structure details

Reducing Mass: 894.35
(Calculated Monoisotopic)

Reducing End: Reduced

Persubstitution: Underivatised

Biological Context

Taxonomy - Homo Sapiens
Tissue - Brain

HPLC

Column

Method

  • 78 min gradient with approx 3-5 ul/min (static split from 250 ul/min) run rate
  • 10 mM (NH4)HCO3
  • 10 mM (NH4)HCO3 in 80% acetonitrile

Mass Spec

Thermo Fisher LTQ Linear Ion Trap ESI

MIRAGE Structural data

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