Core-2 O-glycans are required for galectin-3 interaction with synovial lubricin
File Name: bPRG4_Tina.gwp
GlycoPOST Entry: GPST000060
GlyTouCan Accession Number: Loading...
Peak | Intensity |
---|---|
101.02 | 0.1 |
Annotations: B C Z ^{2,4}A_{GalNAc} Y ^{1,3}A_{GalNAc} ^{1,3}A_{GalNAc} ^{2,5}A_{GalNAc} ^{2,5}A_{GalNAc} ^{0,2}A_{GalNAc} ^{0,2}A_{GalNAc} ^{1,4}A_{GalNAc} ^{1,4}A_{GalNAc} ^{1,5}A_{GalNAc} ^{1,5}A_{GalNAc} |
|
101.59 | 0.0 |
Annotations: B Z C Y Y ^{2,4}A_{GalNAc} ^{2,4}A_{GalNAc} ^{1,3}A_{GalNAc} ^{2,5}A_{GalNAc} ^{2,5}A_{GalNAc} ^{0,2}A_{GalNAc} ^{0,2}A_{GalNAc} ^{1,4}A_{GalNAc} ^{1,4}A_{GalNAc} ^{1,5}A_{GalNAc} |
|
102.11 | 0.0 |
Annotations: ^{2,5}X_{Gal} ^{2,5}X_{Gal} Z Z B ^{0,2}X_{Gal} ^{0,2}X_{Gal} C ^{2,5}X_{Gal} ^{2,5}X_{Gal} ^{0,3}X_{Gal} ^{1,4}X_{Gal} ^{0,3}X_{Gal} ^{1,4}X_{Gal} ^{3,5}X_{Gal} ^{3,5}X_{Gal} ^{3,5}X_{Gal} ^{0,4}X_{Gal} ^{1,3}X_{Gal} ^{2,4}X_{Gal} ^{0,4}X_{Gal} ^{1,3}X_{Gal} ^{2,4}X_{Gal} Z Z Y Y ^{0,2}X_{Gal} ^{0,2}X_{Gal} Z Z ^{0,3}X_{Gal} ^{1,4}X_{Gal} ^{0,3}X_{Gal} ^{1,4}X_{Gal} Y Y ^{3,5}X_{Gal} ^{3,5}X_{Gal} ^{0,4}X_{Gal} ^{1,3}X_{Gal} ^{2,4}X_{Gal} ^{0,2}X_{Gal} ^{0,3}X_{Gal} ^{1,4}X_{Gal} ^{0,3}X_{Gal} ^{1,4}X_{Gal} ^{3,5}X_{Gal} ^{0,4}X_{Gal} ^{1,3}X_{Gal} ^{2,4}X_{Gal} ^{0,4}X_{Gal} ^{1,3}X_{Gal} ^{2,4}X_{Gal} |
|
102.65 | 0.0 |
Annotations: C ZZ ZZ B ZY YZ C C ^{2,4}A_{GalNAc} ^{2,4}A_{GalNAc} YY ^{0,4}A_{GalNAc} ^{1,3}A_{GalNAc} ^{3,5}A_{GalNAc} ^{3,5}A_{GalNAc} ^{0,3}A_{GalNAc} ^{1,4}A_{GalNAc} ^{0,3}A_{GalNAc} ^{1,4}A_{GalNAc} Z Z Y Y Y Z Y Y ^{2,5}A_{GalNAc} ^{2,5}A_{GalNAc} ^{0,2}A_{GalNAc} ^{0,2}A_{GalNAc} ^{1,5}A_{GalNAc} ^{1,5}A_{GalNAc} |
|
103.19 | 0.0 |
Annotations: B B ZY YZ C ^{2,4}A_{GalNAc} ^{2,4}A_{GalNAc} YY B C C ^{0,4}A_{GalNAc} ^{0,3}A_{GalNAc} ^{0,3}A_{GalNAc} Z Y Y ^{2,5}A_{GalNAc} Z Z Y ^{2,5}A_{GalNAc} ^{2,5}A_{GalNAc} |
|
103.72 | 0.0 |
Annotations: ^{2,4}A_{GalNAc}Z ^{2,4}A_{GalNAc}Z Z ^{2,4}A_{GalNAc}Y Y ^{1,3}A_{GalNAc}Z ^{1,3}A_{GalNAc}Z ^{2,5}A_{GalNAc}Z ^{1,3}A_{GalNAc}Y ^{0,2}A_{GalNAc}Z ^{0,2}A_{GalNAc}Z ^{2,5}A_{GalNAc}Y ^{2,5}A_{GalNAc}Y ^{1,4}A_{GalNAc}Z ^{1,4}A_{GalNAc}Z ^{0,2}A_{GalNAc}Y B ^{1,4}A_{GalNAc}Y ^{1,4}A_{GalNAc}Y C ^{1,5}A_{GalNAc}Z ^{1,5}A_{GalNAc}Z ^{1,5}A_{GalNAc}Z ^{1,5}A_{GalNAc}Y ^{1,5}A_{GalNAc}Y ^{1,3}A_{Gal} ^{2,4}A_{Gal} ^{1,3}A_{Gal} ^{2,4}A_{Gal} Z Z ^{1,4}A_{Gal} Y ^{2,5}A_{Gal} ^{0,2}A_{Gal} ^{1,5}A_{Gal} ^{1,5}A_{Gal} B C ^{2,4}A_{GalNAc} ^{1,3}A_{GalNAc} ^{1,3}A_{GalNAc} ^{2,5}A_{GalNAc} ^{2,5}A_{GalNAc} ^{0,2}A_{GalNAc} ^{0,2}A_{GalNAc} ^{1,4}A_{GalNAc} ^{1,4}A_{GalNAc} ^{1,5}A_{GalNAc} ^{1,5}A_{GalNAc} |
|
104.28 | 0.0 |
Annotations: CY CY ^{2,4}A_{GalNAc} ^{2,4}A_{GlcNAc} YY ^{3,5}A_{GlcNAc} ^{0,4}A_{GalNAc}Z ^{0,4}A_{GalNAc}Z ^{0,3}A_{GlcNAc} ^{0,3}A_{GlcNAc} ^{3,5}A_{GalNAc}Z ^{3,5}A_{GalNAc}Z ^{0,4}A_{GalNAc}Y ^{1,3}A_{GalNAc} ^{2,5}A_{GlcNAc} ^{2,5}A_{GlcNAc} ^{0,3}A_{GalNAc}Z ^{3,5}A_{GalNAc}Y ^{3,5}A_{GalNAc}Y ^{0,2}A_{GlcNAc} ^{0,3}A_{GalNAc}Y ^{1,4}A_{GalNAc} ^{1,4}A_{GlcNAc} ^{0,3}A_{GalNAc}Y ^{1,4}A_{GalNAc} ^{1,4}A_{GlcNAc} ^{1,5}A_{GlcNAc} B Z Z C C Y ZZ ZY YZ ^{0,4}A_{GalNAc} ^{0,4}A_{GalNAc} YY ^{3,5}A_{GalNAc} ^{3,5}A_{GalNAc} ^{3,5}A_{GalNAc} ^{2,5}A_{GalNAc}Z ^{2,5}A_{GalNAc}Z ^{0,3}A_{GalNAc} ^{0,3}A_{GalNAc} ^{0,2}A_{GalNAc}Z ^{2,5}A_{GalNAc}Y ^{2,5}A_{GalNAc}Y ^{0,2}A_{GalNAc}Y ^{0,2}A_{GalNAc}Y ^{1,5}A_{GalNAc}Z ^{1,5}A_{GalNAc}Z ^{1,5}A_{GalNAc}Y ^{1,5}A_{GalNAc}Y Z Z Y Y ^{2,5}A_{GalNAc} ^{2,5}A_{GalNAc} ^{2,5}A_{GalNAc} ^{0,2}A_{GalNAc} ^{1,5}A_{GalNAc} ^{1,5}A_{GalNAc} |
|
104.8 | 0.0 |
Annotations: ^{0,2}A_{GalNAc} ^{2,5}A_{GalNAc} ^{0,2}A_{GalNAc} ^{0,4}A_{GalNAc}Z ^{0,4}A_{GalNAc}Z ^{0,4}A_{GalNAc}Y ^{1,3}A_{GalNAc} ^{3,5}A_{GalNAc}Y ^{3,5}A_{GalNAc}Y ^{0,3}A_{GalNAc}Y ^{1,4}A_{GalNAc} Z Z Y ZZ ZZ B ZY YZ C YY YY ^{2,5}A_{GalNAc}Z ^{0,4}A_{GalNAc} ^{0,4}A_{GalNAc} ^{0,2}A_{GalNAc}Z ^{0,2}A_{GalNAc}Z ^{2,5}A_{GalNAc}Y ^{2,5}A_{GalNAc}Y ^{3,5}A_{GalNAc} ^{0,2}A_{GalNAc}Y ^{0,2}A_{GalNAc}Y ^{0,3}A_{GalNAc} Z Z Y Z Y |
|
105.36 | 0.0 |
Annotations: ^{0,4}A_{GalNAc}Z ^{0,4}A_{GalNAc}Z ^{0,4}A_{GalNAc}Y ^{1,3}A_{GalNAc} ^{0,4}A_{GalNAc}Y ^{1,3}A_{GalNAc} BZ BZ ^{0,3}A_{GalNAc}Z ^{0,3}A_{GalNAc}Z ^{3,5}A_{GalNAc}Y BY CZ ^{0,3}A_{GalNAc}Y ^{1,4}A_{GalNAc} ^{0,3}A_{GalNAc}Y ^{1,4}A_{GalNAc} CY ^{0,4}A_{GalNAc}Z ^{0,4}A_{GalNAc}Z ^{0,4}A_{GalNAc}Y ^{0,4}A_{GalNAc}Y ^{0,3}A_{GalNAc}Z ^{3,5}A_{GalNAc}Y ^{3,5}A_{GalNAc}Y B Z Z ^{0,3}A_{GalNAc}Y C Y Y ZZ ZZ ZY YZ ^{0,4}A_{GalNAc} ^{0,4}A_{GalNAc} YY ^{3,5}A_{GalNAc} ^{3,5}A_{GalNAc} B ^{2,5}A_{GalNAc}Z ^{2,5}A_{GalNAc}Z C ^{0,2}A_{GalNAc}Z ^{2,5}A_{GalNAc}Y ^{2,5}A_{GalNAc}Y ZZ ZY YZ ^{0,4}A_{GalNAc} YY ^{2,5}A_{GalNAc}Z ^{0,3}A_{GalNAc} ^{0,3}A_{GalNAc} ^{1,5}A_{GalNAc}Y ^{1,5}A_{GalNAc}Y ^{0,2}A_{GalNAc}Z ^{2,5}A_{GalNAc}Y ^{0,2}A_{GalNAc}Y ^{0,2}A_{GalNAc}Y Z Z Z Z Y Y ^{1,5}A_{GalNAc}Z ^{1,5}A_{GalNAc}Z ^{1,5}A_{GalNAc}Y ^{2,5}A_{GalNAc} ^{2,5}A_{GalNAc} ^{0,2}A_{GalNAc} Z Z Y Y ^{1,5}A_{GalNAc} ^{1,5}A_{GalNAc} ^{2,5}A_{GalNAc} ^{2,5}A_{GalNAc} ^{0,2}A_{GalNAc} ^{1,5}A_{GalNAc} |
|
105.87 | 0.0 |
Annotations: Too many annotations to display (≥ 100). |
|
108.0 | 0.1 |
Annotations: Too many annotations to display (≥ 100). |
|
108.55 | 0.0 |
Annotations: Too many annotations to display (≥ 100). |
|
108.96 | 0.1 |
Annotations: Too many annotations to display (≥ 100). |
|
109.21 | 0.1 |
Annotations: Too many annotations to display (≥ 100). |
|
110.02 | 0.1 |
Annotations: Too many annotations to display (≥ 100). |
|
110.6 | 0.0 |
Annotations: Too many annotations to display (≥ 100). |
|
111.12 | 0.0 |
Annotations: Too many annotations to display (≥ 100). |
|
112.1 | 2.7 |
Annotations: Too many annotations to display (≥ 100). |
|
113.06 | 25.6 |
Annotations: Too many annotations to display (≥ 100). |
|
114.12 | 13.6 |
Annotations: Too many annotations to display (≥ 100). |
|
114.98 | 1.8 |
Annotations: Too many annotations to display (≥ 100). |
|
115.63 | 0.0 |
Annotations: Too many annotations to display (≥ 100). |
|
116.17 | 0.0 |
Annotations: Too many annotations to display (≥ 100). |
|
116.71 | 0.0 |
Annotations: Too many annotations to display (≥ 100). |
|
117.25 | 0.0 |
118.95 | 10.7 |
119.72 | 0.1 |
120.31 | 0.0 |
120.82 | 0.0 |
121.39 | 0.0 |
121.9 | 0.0 |
122.46 | 0.0 |
122.86 | 0.2 |
123.41 | 0.0 |
123.95 | 0.0 |
125.04 | 4.1 |
126.05 | 53.4 |
127.02 | 1.5 |
127.65 | 0.0 |
128.48 | 0.1 |
128.9 | 0.2 |
129.23 | 0.2 |
129.67 | 0.1 |
130.32 | 0.8 |
131.08 | 6.5 |
131.93 | 0.1 |
132.26 | 0.1 |
132.8 | 0.0 |
133.36 | 0.0 |
133.88 | 0.0 |
134.44 | 0.0 |
134.96 | 0.0 |
135.52 | 0.0 |
136.04 | 0.0 |
136.6 | 0.0 |
138.04 | 51.5 |
138.68 | 0.5 |
139.04 | 0.1 |
139.23 | 0.1 |
139.77 | 0.0 |
140.24 | 0.1 |
141.05 | 0.1 |
141.47 | 0.1 |
141.89 | 0.3 |
143.03 | 36.7 |
144.06 | 0.7 |
144.71 | 0.1 |
145.02 | 0.2 |
145.58 | 0.0 |
146.1 | 0.0 |
146.67 | 0.0 |
147.18 | 0.0 |
147.75 | 0.0 |
148.96 | 4.7 |
150.06 | 0.2 |
150.61 | 0.0 |
151.05 | 0.0 |
151.61 | 0.0 |
152.15 | 0.0 |
152.69 | 0.0 |
153.22 | 0.0 |
153.78 | 0.0 |
154.75 | 0.4 |
156.0 | 215.9 |
157.02 | 1.3 |
157.28 | 1.0 |
157.7 | 0.1 |
158.27 | 0.0 |
158.79 | 0.2 |
159.43 | 0.3 |
159.95 | 0.7 |
160.93 | 38.8 |
162.03 | 7.7 |
162.7 | 0.0 |
163.25 | 0.0 |
163.78 | 0.0 |
164.32 | 0.0 |
164.84 | 0.0 |
165.4 | 0.0 |
165.94 | 0.0 |
166.47 | 0.0 |
167.01 | 0.0 |
167.97 | 0.9 |
168.42 | 0.0 |
168.87 | 0.0 |
169.44 | 0.0 |
169.96 | 0.0 |
170.52 | 0.0 |
171.04 | 0.0 |
171.92 | 0.6 |
172.47 | 0.0 |
173.15 | 0.1 |
173.79 | 1.1 |
174.09 | 0.3 |
174.67 | 0.1 |
175.22 | 0.0 |
175.99 | 0.1 |
176.93 | 0.6 |
178.89 | 120.4 |
179.89 | 0.7 |
180.16 | 0.2 |
180.74 | 0.0 |
181.24 | 0.0 |
181.81 | 0.0 |
182.32 | 0.0 |
183.41 | 0.0 |
183.75 | 0.1 |
184.31 | 0.0 |
184.86 | 0.0 |
185.98 | 3.6 |
187.06 | 0.2 |
187.66 | 0.0 |
188.17 | 0.0 |
188.74 | 0.0 |
189.25 | 0.0 |
189.58 | 0.0 |
190.13 | 0.0 |
190.69 | 0.0 |
191.21 | 0.0 |
191.77 | 0.0 |
192.32 | 0.0 |
192.87 | 0.0 |
193.44 | 0.0 |
193.95 | 0.0 |
194.51 | 0.0 |
194.87 | 0.1 |
195.44 | 0.0 |
196.05 | 0.1 |
196.61 | 0.0 |
197.11 | 0.0 |
197.69 | 0.0 |
198.2 | 0.0 |
198.89 | 0.1 |
199.45 | 0.0 |
200.01 | 0.0 |
200.48 | 0.1 |
200.84 | 0.1 |
201.56 | 0.1 |
202.11 | 0.1 |
202.56 | 0.1 |
203.99 | 696.9 |
204.99 | 3.8 |
206.08 | 0.2 |
206.65 | 0.1 |
207.2 | 0.0 |
207.76 | 0.0 |
208.28 | 0.0 |
209.01 | 0.1 |
209.57 | 0.0 |
210.3 | 0.1 |
210.86 | 0.0 |
211.39 | 0.0 |
211.94 | 0.0 |
212.46 | 0.0 |
212.79 | 0.0 |
213.02 | 0.0 |
213.81 | 0.1 |
214.37 | 0.0 |
214.92 | 0.0 |
215.45 | 0.0 |
215.98 | 0.0 |
216.53 | 0.0 |
217.06 | 0.0 |
217.61 | 0.0 |
218.13 | 0.0 |
218.69 | 0.0 |
220.84 | 0.2 |
222.02 | 49.7 |
223.13 | 3.2 |
224.04 | 0.2 |
224.69 | 0.1 |
225.27 | 0.0 |
225.79 | 0.0 |
226.35 | 0.0 |
226.87 | 0.0 |
227.41 | 0.0 |
227.92 | 0.1 |
228.45 | 0.0 |
229.02 | 0.0 |
229.53 | 0.0 |
230.08 | 0.0 |
230.61 | 0.0 |
231.15 | 0.0 |
231.69 | 0.0 |
232.22 | 0.0 |
232.77 | 0.0 |
233.45 | 0.1 |
234.0 | 1.2 |
234.52 | 0.1 |
235.04 | 0.0 |
236.05 | 0.3 |
236.36 | 0.0 |
236.61 | 0.0 |
237.13 | 0.0 |
237.44 | 0.0 |
237.69 | 0.0 |
238.48 | 0.0 |
239.04 | 0.0 |
239.6 | 0.1 |
239.86 | 0.1 |
240.16 | 0.0 |
240.44 | 0.0 |
240.95 | 0.0 |
241.24 | 0.0 |
241.51 | 0.0 |
242.03 | 0.0 |
242.55 | 0.0 |
243.11 | 0.0 |
243.88 | 0.1 |
244.19 | 0.0 |
244.44 | 0.0 |
244.95 | 0.0 |
245.52 | 0.0 |
246.1 | 0.8 |
246.67 | 0.0 |
247.21 | 0.0 |
247.75 | 0.0 |
248.29 | 0.0 |
248.83 | 0.0 |
249.37 | 0.0 |
249.9 | 0.0 |
250.64 | 0.1 |
251.19 | 0.0 |
251.71 | 0.0 |
252.27 | 0.0 |
253.02 | 0.2 |
253.35 | 0.0 |
253.6 | 0.0 |
254.12 | 0.0 |
254.67 | 0.0 |
255.2 | 0.0 |
255.74 | 0.0 |
256.28 | 0.0 |
256.8 | 0.1 |
257.4 | 0.0 |
257.91 | 0.0 |
258.48 | 0.0 |
258.99 | 0.0 |
259.51 | 0.0 |
260.07 | 0.0 |
260.59 | 0.0 |
261.15 | 0.0 |
261.66 | 0.0 |
262.2 | 0.2 |
263.01 | 1.5 |
263.47 | 2.4 |
263.93 | 1.4 |
264.51 | 0.0 |
264.73 | 0.0 |
265.21 | 0.0 |
265.77 | 0.0 |
266.3 | 0.0 |
266.86 | 0.0 |
267.37 | 0.0 |
267.94 | 0.0 |
268.45 | 0.0 |
269.02 | 0.0 |
269.53 | 0.0 |
269.86 | 0.1 |
270.43 | 0.0 |
270.95 | 0.0 |
271.49 | 0.0 |
272.03 | 0.0 |
272.56 | 0.0 |
273.11 | 0.0 |
273.68 | 0.1 |
274.23 | 0.0 |
275.01 | 0.2 |
275.96 | 39.5 |
277.04 | 0.4 |
277.61 | 0.0 |
278.14 | 0.0 |
278.7 | 0.0 |
279.23 | 0.0 |
279.78 | 0.1 |
280.35 | 0.0 |
280.7 | 0.1 |
281.27 | 0.0 |
281.79 | 0.0 |
282.35 | 0.0 |
282.87 | 0.0 |
283.41 | 0.0 |
283.95 | 0.0 |
284.48 | 0.0 |
285.03 | 0.0 |
285.54 | 0.0 |
287.96 | 0.1 |
288.78 | 0.1 |
289.02 | 0.1 |
289.32 | 0.0 |
289.6 | 0.0 |
290.11 | 0.0 |
290.39 | 0.0 |
290.69 | 0.0 |
291.19 | 0.0 |
291.77 | 0.0 |
292.29 | 0.0 |
292.94 | 0.3 |
293.88 | 0.4 |
294.18 | 0.1 |
294.63 | 0.1 |
295.07 | 0.1 |
295.62 | 0.0 |
296.18 | 0.0 |
296.7 | 0.0 |
297.24 | 0.0 |
297.8 | 0.0 |
298.36 | 0.0 |
298.77 | 0.1 |
299.32 | 0.0 |
299.86 | 0.0 |
300.39 | 0.0 |
300.94 | 0.0 |
301.46 | 0.0 |
302.02 | 0.0 |
302.54 | 0.0 |
303.1 | 0.0 |
303.61 | 0.0 |
305.01 | 0.0 |
305.57 | 0.0 |
306.11 | 0.0 |
306.64 | 0.0 |
307.19 | 0.0 |
307.72 | 0.0 |
308.27 | 0.0 |
308.79 | 0.0 |
309.35 | 0.0 |
309.86 | 0.0 |
310.58 | 0.2 |
310.86 | 0.2 |
311.41 | 0.0 |
311.95 | 0.0 |
312.48 | 0.0 |
313.03 | 0.0 |
313.55 | 0.0 |
314.11 | 0.0 |
314.63 | 0.0 |
315.19 | 0.0 |
315.7 | 0.0 |
316.43 | 0.1 |
316.96 | 0.0 |
317.52 | 0.0 |
318.04 | 0.0 |
318.6 | 0.0 |
319.12 | 0.0 |
319.67 | 0.0 |
320.2 | 0.0 |
320.54 | 0.1 |
321.14 | 0.3 |
321.86 | 0.0 |
322.31 | 0.1 |
323.99 | 34.7 |
324.99 | 0.6 |
325.49 | 0.1 |
326.03 | 0.0 |
326.72 | 0.2 |
327.27 | 0.0 |
327.79 | 0.0 |
328.35 | 0.0 |
328.87 | 0.0 |
329.44 | 0.0 |
329.95 | 0.0 |
330.51 | 0.0 |
331.03 | 0.0 |
331.57 | 0.0 |
335.8 | 0.2 |
336.37 | 0.0 |
336.88 | 0.0 |
337.43 | 0.0 |
338.14 | 0.0 |
338.65 | 0.3 |
338.89 | 0.4 |
339.49 | 0.0 |
339.98 | 0.1 |
340.53 | 0.0 |
341.01 | 0.0 |
341.3 | 0.1 |
341.99 | 2.3 |
342.6 | 0.0 |
343.15 | 0.0 |
343.68 | 0.0 |
344.22 | 0.0 |
344.76 | 0.0 |
345.29 | 0.0 |
345.84 | 0.0 |
346.37 | 0.0 |
346.87 | 0.1 |
347.13 | 0.1 |
347.96 | 0.4 |
348.2 | 0.4 |
348.73 | 0.0 |
349.3 | 0.0 |
349.81 | 0.0 |
350.38 | 0.0 |
350.87 | 0.1 |
351.44 | 0.0 |
351.95 | 0.0 |
352.49 | 0.0 |
353.03 | 0.0 |
353.63 | 0.1 |
353.99 | 0.4 |
354.55 | 0.0 |
355.08 | 0.0 |
355.62 | 0.0 |
356.18 | 0.0 |
357.0 | 0.0 |
357.55 | 0.0 |
358.11 | 0.0 |
358.63 | 0.0 |
359.19 | 0.0 |
359.7 | 0.0 |
360.27 | 0.0 |
360.78 | 0.0 |
361.34 | 0.0 |
361.86 | 0.0 |
383.3 | 0.0 |
384.0 | 0.1 |
384.56 | 0.0 |
385.11 | 0.0 |
385.63 | 0.0 |
386.19 | 0.0 |
386.71 | 0.0 |
387.27 | 0.0 |
387.79 | 0.0 |
388.35 | 0.0 |
388.86 | 0.0 |
There are 43 similar spectra: