Structure

    redEnd--??1D-GalNAc,p(--3b1D-Gal,p--3a2D-NeuAc,p)--6b1D-GlcNAc,p--4b1D-Gal,p$MONO,Und,-H,0,redEnd

The O-glycome of human nigrostriatal tissue and its alteration in Parkinsons disease

GlyTouCan Accession Number: Loading...

Peak Intensity
290.12 4.6

Annotations:

B b1D-Gal,p/#bcleavage--3a2D-NeuAc,p$MONO,Und,-H,0,redEnd
291.13 0.4
347.31 0.5
364.25 0.9

Annotations:

B ?1D-GalNAc,p/#bcleavage--6b1D-GlcNAc,p--4b1D-Gal,p$MONO,Und,-H,0,redEnd
389.16 5.5

Annotations:

ZZ redEnd--??1D-GalNAc,p(--3b1D-Gal,p/#zcleavage)--6b1D-GlcNAc,p--4b1D-Gal,p/#zcleavage$MONO,Und,-H,0,redEnd
389.43 2.1

Annotations:

ZZ redEnd--??1D-GalNAc,p(--3b1D-Gal,p/#zcleavage)--6b1D-GlcNAc,p--4b1D-Gal,p/#zcleavage$MONO,Und,-H,0,redEnd
405.33 0.4
407.24 2.6

Annotations:

YZ redEnd--??1D-GalNAc,p(--3b1D-Gal,p/#ycleavage)--6b1D-GlcNAc,p--4b1D-Gal,p/#zcleavage$MONO,Und,-H,0,redEnd ZY redEnd--??1D-GalNAc,p(--3b1D-Gal,p/#zcleavage)--6b1D-GlcNAc,p--4b1D-Gal,p/#ycleavage$MONO,Und,-H,0,redEnd
408.37 0.8
416.35 0.9
424.23 1.9

Annotations:

^{1,5}A_{Gal} b1D-Gal,p/#acleavage_1_5--3a2D-NeuAc,p$MONO,Und,-H,0,redEnd ^{0,4}A_{GalNAc} ?1D-GalNAc,p/#acleavage_0_4--6b1D-GlcNAc,p--4b1D-Gal,p$MONO,Und,-H,0,redEnd
425.11 0.7

Annotations:

YY redEnd--??1D-GalNAc,p(--3b1D-Gal,p/#ycleavage)--6b1D-GlcNAc,p--4b1D-Gal,p/#ycleavage$MONO,Und,-H,0,redEnd
425.33 0.5

Annotations:

YY redEnd--??1D-GalNAc,p(--3b1D-Gal,p/#ycleavage)--6b1D-GlcNAc,p--4b1D-Gal,p/#ycleavage$MONO,Und,-H,0,redEnd
471.35 0.6
508.94 0.7
509.45 0.8
510.34 0.6
521.18 0.7
527.45 4.3
528.29 0.6
545.35 1.0
551.29 1.8

Annotations:

ZZ redEnd--??1D-GalNAc,p(--3b1D-Gal,p--3a2D-NeuAc,p/#zcleavage)--6b1D-GlcNAc,p--4b1D-Gal,p/#zcleavage$MONO,Und,-H,0,redEnd
552.35 0.4
569.3 55.7

Annotations:

YZ redEnd--??1D-GalNAc,p(--3b1D-Gal,p--3a2D-NeuAc,p/#ycleavage)--6b1D-GlcNAc,p--4b1D-Gal,p/#zcleavage$MONO,Und,-H,0,redEnd ZY redEnd--??1D-GalNAc,p(--3b1D-Gal,p--3a2D-NeuAc,p/#zcleavage)--6b1D-GlcNAc,p--4b1D-Gal,p/#ycleavage$MONO,Und,-H,0,redEnd Z redEnd--??1D-GalNAc,p(--3b1D-Gal,p/#zcleavage)--6b1D-GlcNAc,p--4b1D-Gal,p$MONO,Und,-H,0,redEnd
570.47 3.3
584.21 0.4
587.35 18.6

Annotations:

YY redEnd--??1D-GalNAc,p(--3b1D-Gal,p--3a2D-NeuAc,p/#ycleavage)--6b1D-GlcNAc,p--4b1D-Gal,p/#ycleavage$MONO,Und,-H,0,redEnd Y redEnd--??1D-GalNAc,p(--3b1D-Gal,p/#ycleavage)--6b1D-GlcNAc,p--4b1D-Gal,p$MONO,Und,-H,0,redEnd
588.34 5.1
588.67 1.1
589.25 1.1
596.37 0.6
602.33 0.4
607.61 0.4
637.26 0.5
663.87 0.4
675.58 1.8

Annotations:

Y redEnd--??1D-GalNAc,p(--3b1D-Gal,p--3a2D-NeuAc,p)--6b1D-GlcNAc,p/#ycleavage$MONO,Und,-H,0,redEnd
676.23 3.5
676.57 0.9
689.34 2.3
690.44 0.4
697.44 0.5
704.21 0.4
707.38 2.6
708.27 0.7
722.38 0.4
731.47 1.0

Annotations:

Z redEnd--??1D-GalNAc,p(--3b1D-Gal,p--3a2D-NeuAc,p/#zcleavage)--6b1D-GlcNAc,p--4b1D-Gal,p$MONO,Und,-H,0,redEnd
745.36 2.8
747.36 0.9
747.59 0.4
748.6 1.6
749.34 70.1

Annotations:

Y redEnd--??1D-GalNAc,p(--3b1D-Gal,p--3a2D-NeuAc,p/#ycleavage)--6b1D-GlcNAc,p--4b1D-Gal,p$MONO,Und,-H,0,redEnd
750.4 10.7
751.35 0.5
791.41 1.3
796.54 0.5
801.37 0.5
803.11 0.4
819.77 0.6
820.39 0.5
829.42 0.4
838.62 0.6
839.7 0.4
842.25 1.2
842.6 0.5
844.74 0.4
846.41 0.5
854.32 0.9
859.33 1.3
877.44 0.4
877.96 0.5

Annotations:

Y redEnd--??1D-GalNAc,p(--3b1D-Gal,p--3a2D-NeuAc,p)--6b1D-GlcNAc,p--4b1D-Gal,p/#ycleavage$MONO,Und,-H,0,redEnd
878.44 0.5

Annotations:

Y redEnd--??1D-GalNAc,p(--3b1D-Gal,p--3a2D-NeuAc,p)--6b1D-GlcNAc,p--4b1D-Gal,p/#ycleavage$MONO,Und,-H,0,redEnd
879.31 2.2
879.61 1.4
885.4 0.9
897.56 0.8
934.14 0.5
937.65 0.7

Annotations:

^{0,2}A_{GalNAc} ?1D-GalNAc,p/#acleavage_0_2(--3b1D-Gal,p--3a2D-NeuAc,p)--6b1D-GlcNAc,p--4b1D-Gal,p$MONO,Und,-H,0,redEnd
939.6 0.5
940.39 0.4
940.99 0.8
941.46 0.8
943.37 0.6
954.74 0.4
959.57 0.6
960.31 0.5
962.4 22.1
963.29 4.6
963.61 2.4
967.27 0.8
978.41 0.4
979.53 0.6
980.48 11.4
981.42 2.0
981.68 1.3
982.75 0.7
986.38 0.5
1004.21 1.5
1004.58 1.8
1005.48 0.8
1005.9 0.6

There are 52 similar spectra:

Id Structure Score

1.00

3894

0.99

3510

0.99

4248

0.98

5240

0.98

5739

0.98

5590

0.98

0.97

4877

0.97

4085

0.97

5448

0.97

5191

0.96

8026

0.96

8027

0.96

0.95

4212

0.95

5210

0.95

4249

0.94

5241

0.94

5179

0.94

7229

0.93

7228

0.93

7413

0.92

7442

0.92

3980

0.92

3511

0.92

0.92

6594

0.92

3138

0.91

5449

0.90

5804

0.90

3766

0.88

0.87

5740

0.87

5184

0.85

5803

0.85

5185

0.84

8028

0.82

4250

0.82

5242

0.82

0.81

5741

0.78

5186

0.75

5805

0.74

7632

0.74

3981

0.72

3979

0.63

4084

0.60

7958

0.54

4213

0.54

8025

0.53

3982

0.50

Structure Format

SNFG Oxford Text

Structure details

Reducing Mass: 1039.39
(Calculated Monoisotopic)

Reducing End: Reduced

Persubstitution: Underivatised

Biological Context

Taxonomy - Homo Sapiens
Tissue - Brain

HPLC

Column

Method

  • 78 min gradient with approx 3-5 ul/min (static split from 250 ul/min) run rate
  • 10 mM (NH4)HCO3
  • 10 mM (NH4)HCO3 in 80% acetonitrile

Mass Spec

Thermo Fisher LTQ Linear Ion Trap ESI

MIRAGE Structural data

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